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Article

Aquaporin-4 Mediates Permanent Brain Alterations in a Mouse Model of Hypoxia-Aged Hydrocephalus.

International journal of molecular sciences - 9 Sept 2021

Trillo-Contreras José Luis, Toledo-Aral Juan José, Villadiego Javier, Echevarría Miriam

Abstract excerpt

Aquaporin-4 (AQP4) is the principal water channel in the brain being expressed in astrocytes and ependymal cells. AQP4 plays an important role in cerebrospinal fluid (CSF) homeostasis, and alterations in its expression have been associated with hydrocephalus. AQP4 contributes to the development of hydrocephalus by hypoxia in aged mice, reproducing such principal characteristics of the disease. Here, we explore...

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Identifiers

PMID: 34575909
DOI: 10.3390/ijms22189745
PMCID: PMC8471142

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