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Article

Aquaporin-4 deficiency induced white matter injury via upregulated complement component 3 in cerebral small vessel disease.

Journal of neuroinflammation - 21 Jan 2026

Chen Yun, Jiang Lingling, Yao Dongxiao, Liu Dandan, Pan Yuesong, Wang Yilong

Abstract excerpt

BACKGROUND: Cerebral small vessel disease (CSVD) is the most common neurological disorder associated with a high incidence of stroke and dementia. For the heterogeneity of the pathogenesis, effective preventive and therapeutic strategies remain limited. Reduced aquaporin-4 (AQP4) was reported in the development of CSVD, while its role and mechanisms have not been fully elucidated. METHODS: We employed logistic...

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Identifiers

PMID: 41566527
DOI: 10.1186/s12974-025-03688-w
PMCID: PMC12905901

Genes

AQP4
C3
MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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