Article
Lectin-reactive anti-α-gal in patients with Crohn's disease: correlation with clinical phenotypes.
Inflammatory bowel diseases - 1 Dec 2013
Safaie Parham, Ham Maggie, Kuang Peter, Mehta Anand S, Wang Mengjun, Cheifetz Adam S, Robson Simon, Lau Daryl, Block Timothy M, Moss Alan C
Abstract excerpt
BACKGROUND: Patients with inflammatory bowel disease have higher proportions of immunoglobulin G (IgG) antibodies lacking N-galactose, also called agalactosyl IgG, in their serum. Such agalactosyl IgGs have been associated with disease activity and the immunogenicity of biologics. The aim was to describe the relationship between circulating levels of a subset of agalactosyl IgGs (anti-α-Gal) and Crohn's disease...
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