Article
The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin.
BMC cancer - 4 Nov 2013
Wang Quan, Wei Feng, Lv Guoyue, Li Chunsheng, Liu Tongjun, Hadjipanayis Costas G, Zhang Guikai, Hao Chunhai, Bellail Anita C
Abstract excerpt
BACKGROUND: There is growing evidence indicating the insulin-like growth factor 1 receptor (IGF-1R) plays a critical role in the progression of human colorectal carcinomas. IGF-1R is an attractive drug target for the treatment of colon cancer. Picropodophyllin (PPP), of the cyclolignan family, has recently been identified as an IGF-1R inhibitor. The aim of this study is to determine the therapeutic response and...
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