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Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastoma

20 Oct 2009

Abstract excerpt

Glioblastoma (GB) is the most common malignant brain tumor in adults. It has limited treatment opportunities and is almost exclusively fatal. Owing to the central role the insulin-like growth factor-1 receptor (IGF-1R) plays in malignant cells, it has been suggested as a target for anticancer therapy including GB. The cyclolignan picropodophyllin (PPP) inhibits IGF-1R without affecting the highly homologous...

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PMID: 20150364
DOI: 10.1093/neuonc/nop008

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