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Article

Evidence for activation of mutated p53 by apigenin in human pancreatic cancer.

Biochimica et biophysica acta - 1 Feb 2012

King Jonathan C, Lu Qing-Yi, Li Gang, Moro Aune, Takahashi Hiroki, Chen Monica, Go Vay Liang W, Reber Howard A, Eibl Guido, Hines O Joe

Abstract excerpt

Pancreatic cancer is an exceedingly lethal disease with a five-year survival that ranks among the lowest of gastrointestinal malignancies. Part of its lethality is attributable to a generally poor response to existing chemotherapeutic regimens. New therapeutic approaches are urgently needed. We aimed to elucidate the anti-neoplastic mechanisms of apigenin-an abundant, naturally-occurring plant flavonoid-with a...

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Identifiers

PMID: 22227579
DOI: 10.1016/j.bbamcr.2011.12.008
PMCID: PMC3277744

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Evidence for activation of mutated p53 by apigenin in human pancreatic cancer.PMID 22227579Read ↗

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