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Epithelial–mesenchymal transition: The history, regulatory mechanism, and cancer therapeutic opportunities

18 May 2022

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a program wherein epithelial cells lose their junctions and polarity while acquiring mesenchymal properties and invasive ability. Originally defined as an embryogenesis event, EMT has been recognized as a crucial process in tumor progression. During EMT, cell-cell junctions and cell-matrix attachments are disrupted, and the cytoskeleton is remodeled to enhance mobility...

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PMID: 35601657
DOI: 10.1002/mco2.144

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