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Article

A molecular evolution approach to study the roles of tropomyosin in fission yeast.

PloS one - 1 Jan 2013

Cranz-Mileva Susanne, Pamula Melissa C, Barua Bipasha, Desai Brinda, Hong Yaejee Hannah, Russell Jacquelyn, Trent Richard, Wang Jianqiu, Walworth Nancy C, Hitchcock-DeGregori Sarah E

Abstract excerpt

Tropomyosin, a coiled-coil protein that binds along the length of the actin filament, is a universal regulator of the actin cytoskeleton. We have taken a bioinformatics/proteomic approach to studying structure-function relationships in this protein. The presence of a single, essential tropomyosin gene, cdc8, in fission yeast, Schizosaccharomyces pombe, enables a systems-based approach to define the residues that...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24167549
DOI: 10.1371/journal.pone.0076726
PMCID: PMC3805550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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