Article
Temperature sensitive point mutations in fission yeast tropomyosin have long range effects on the stability and function of the actin-tropomyosin copolymer.
Biochemical and biophysical research communications - 25 Nov 2018
Johnson Chloe A, Brooker Holly R, Gyamfi Irene, O'Brien Jennifer, Ashley Brogan, Brazier Jodie E, Dean Annette, Embling James, Grimsey Elisabeth, Tomlinson Alice C, Wilson Elliot G, Geeves Michael A, Mulvihill Daniel P
Abstract excerpt
The actin cytoskeleton is modulated by regulatory actin-binding proteins which fine-tune the dynamic properties of the actin polymer to regulate function. One such actin-binding protein is tropomyosin (Tpm), a highly-conserved alpha-helical dimer which stabilises actin and regulates interactions with other proteins. Temperature sensitive mutants of Tpm are invaluable tools in the study of actin filament dependent...
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