Article
Structure of Cdc4p, a contractile ring protein essential for cytokinesis in Schizosaccharomyces pombe.
The Journal of biological chemistry - 23 Feb 2001
Slupsky C M, Desautels M, Huebert T, Zhao R, Hemmingsen S M, McIntosh L P
Abstract excerpt
The Schizosaccharomyces pombe Cdc4 protein is required for the formation and function of the contractile ring, presumably acting as a myosin light chain. By using NMR spectroscopy, we demonstrate that purified Cdc4p is a monomeric protein with two structurally independent domains, each exhibiting a fold reminiscent of the EF-hand class of calcium-binding proteins. Although Cdc4p has one potentially functional...
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