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Article

The Role of Cell Density and Intratumoral Heterogeneity in Multidrug Resistance

26 Oct 2013

Abstract excerpt

Recent data have demonstrated that cancer drug resistance reflects complex biologic factors, including tumor heterogeneity, varying growth, differentiation, apoptosis pathways, and cell density. As a result, there is a need to find new ways to incorporate these complexities in the mathematical modeling of multidrug resistance. Here, we derive a novel structured population model that describes the behavior of...

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PMID: 24163380
DOI: 10.1158/0008-5472.can-13-1768

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