Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The impact of cell density and mutations in a model of multidrug resistance in solid tumors.

Bulletin of mathematical biology - 1 Mar 2014

Greene James, Lavi Orit, Gottesman Michael M, Levy Doron

Abstract excerpt

In this paper we develop a mathematical framework for describing multidrug resistance in cancer. To reflect the complexity of the underlying interplay between cancer cells and the therapeutic agent, we assume that the resistance level is a continuous parameter. Our model is written as a system of integro-differential equations that are parameterized by the resistance level. This model incorporates the cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Computer Simulation
Share to Drug Resistance, Multiple

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Mathematical Concepts

Share to Models, Biological

Share to Models, Genetic

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 24553772
DOI: 10.1007/s11538-014-9936-8
PMCID: PMC4794109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The impact of cell density and mutations in a model of multidrug resistance in solid tumors.PMID 24553772Read ↗

The Role of Cell Density and Intratumoral Heterogeneity in Multidrug ResistanceSemantic proximity Read ↗

Modeling the Dynamics of Heterogeneity of Solid Tumors in Response to Chemotherapy.Semantic proximity Read ↗

Drug resistance in cancer mechanisms and modelsSemantic proximity Read ↗

Modeling the chemotherapy-induced selection of drug-resistant traits during tumor growth.Semantic proximity Read ↗

Impact of Resistance on Therapeutic Design: A Moran Model of Cancer GrowthSemantic proximity Read ↗

Stochastic modeling of drug resistance in cancer.Semantic proximity Read ↗

Global analysis of a cancer model with drug resistance due to Lamarckian induction and microvesicle transfer.Semantic proximity Read ↗

The development of drug resistance in metastatic tumours under chemotherapy: An evolutionary perspective.Semantic proximity Read ↗

Drug resistance as a dynamic process in a model for multistep gene amplification under various levels of selection stringency.Semantic proximity Read ↗

Global analysis of a cancer model with drug resistance due to Lamarckian induction and microvesicle transferSemantic proximity Read ↗

Consequences of cell-to-cell P-glycoprotein transfer on acquired multidrug resistance in breast cancer: a cell population dynamics modelSemantic proximity Read ↗

Modelling glioblastoma resistance to temozolomide. A mathematical model to simulate cellular adaptation in vitroSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.