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Toxicological applications of human induced pluripotent stem cell-derived hepatocyte-like cells: an updated review

1 Jan 2023

Abstract excerpt

Variability in supply, paucity of donors and cellular instability under in vitro conditions have limited the application of primary human hepatocytes (PHHs) to hepatotoxicity testing. Therefore, alternative sources have been sought for functional liver cells. Many of the earlier in vitro hepatotoxicity studies were carried out using hepatoma-derived cell lines. These cell lines have overcome some of the...

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PMID: 37532578
DOI: 10.2131/jts.48.441

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