Article
Generalizability of GWA-Identified Genetic Risk Variants for Metabolic Traits to Populations from the Arabian Peninsula.
Genes - 18 Oct 2021
Hebbar Prashantha, Abu-Farha Mohamed, Abubaker Jehad, Channanath Arshad Mohamed, Al-Mulla Fahd, Thanaraj Thangavel Alphonse
Abstract excerpt
The Arabian Peninsula, located at the nexus of Africa, Europe, and Asia, was implicated in early human migration. The Arab population is characterized by consanguinity and endogamy leading to inbreeding. Global genome-wide association (GWA) studies on metabolic traits under-represent the Arab population. Replicability of GWA-identified association signals in the Arab population has not been satisfactorily...
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