PTEN Loss as a Predictor of Tumor Heterogeneity and Poor Prognosis in Patients With EGFR-mutant Advanced Non-small-cell Lung Cancer Receiving Tyrosine Kinase Inhibitors.

doi:10.1016/j.cllc.2020.12.008

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PTEN Loss as a Predictor of Tumor Heterogeneity and Poor Prognosis in Patients With EGFR-mutant Advanced Non-small-cell Lung Cancer Receiving Tyrosine Kinase Inhibitors.

Clinical lung cancer - 1 Jul 2021

Ferrara Miriam Grazia, Martini Maurizio, D'Argento Ettore, Forcella Chiara, Vita Emanuele, Di Noia Vincenzo, Sperduti Isabella, Bilotta Mirna, Ribelli Marta, Damiano Paola, Cannella Antonella, Stefani Alessio, Pilotto Sara, Carbone Carmine, Piro Geny, Milella Michele, Tortora Giampaolo, Bria Emilio

Abstract excerpt

BACKGROUND: Rapid disease progression of patients with advanced epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancer (NSCLC) has been recently associated with tumor heterogeneity, which may be mirrored by coexisting concomitant alterations. The aim of this analysis was to investigate the correlation between loss of function of PTEN and the efficacy of tyrosine kinase inhibitors in this...

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PMID: 33558194
DOI: 10.1016/j.cllc.2020.12.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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