Article
Somatic PTEN and ARID1A loss and endometriosis disease burden: a longitudinal study.
Human reproduction (Oxford, England) - 1 Feb 2025
Tucker Dwayne R, Lee Anna F, Orr Natasha L, Alotaibi Fahad T, Noga Heather L, Williams Christina, Allaire Catherine, Bedaiwy Mohamed A, Huntsman David G, Köbel Martin, Anglesio Michael S, Yong Paul J
Abstract excerpt
STUDY QUESTION: Is there an association between the somatic loss of PTEN (phosphatase and tensin homolog) and ARID1A (AT-rich interaction domain 1A) and endometriosis disease severity and worse clinical outcomes? SUMMARY ANSWER: Somatic PTEN loss in endometriosis epithelium was associated with greater disease burden and subsequent surgical complexity. WHAT IS KNOWN ALREADY: Somatic cancer-driver mutations...
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