Article
Genetic risk transmission in a family affected by familial breast cancer.
Journal of human genetics - 1 Jan 2014
Pilato Brunella, De Summa Simona, Danza Katia, Lacalamita Rosanna, Lambo Rossana, Sambiasi Domenico, Paradiso Angelo, Tommasi Stefania
Abstract excerpt
Breast Cancer is the most common malignancy among women. Family history is the strongest single predictor of breast cancer risk, and thus great attention has been focused on BRCA1 and BRCA2 genes whose mutations lead to a high risk of developing this disease. Today, only 25% of high- and moderate-risk genes are known, suggesting the importance of the discovery of new risk modifiers. Therefore, the investigation...
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