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Article

Digital holographic microscopy: a quantitative label-free microscopy technique for phenotypic screening.

Combinatorial chemistry & high throughput screening - 1 Jan 2014

Rappaz Benjamin, Breton Billy, Shaffer Etienne, Turcatti Gerardo

Abstract excerpt

Digital Holographic Microscopy (DHM) is a label-free imaging technique allowing visualization of transparent cells with classical imaging cell culture plates. The quantitative DHM phase contrast image provided is related both to the intracellular refractive index and to cell thickness. DHM is able to distinguish cellular morphological changes on two representative cell lines (HeLa and H9c2) when treated with...

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Identifiers

PMID: 24152227
DOI: 10.2174/13862073113166660062
PMCID: PMC3894694

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