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Quantifying cellular differentiation by physical phenotype using digital holographic microscopy.

Integrative biology : quantitative biosciences from nano to macro - 1 Mar 2012

Chalut Kevin J, Ekpenyong Andrew E, Clegg Warren L, Melhuish Isabel C, Guck Jochen

Abstract excerpt

Although the biochemical changes that occur during cell differentiation are well-known, less known is that there are significant, cell-wide physical changes that also occur. Understanding and quantifying these changes can help to better understand the process of differentiation as well as ways to monitor it. Digital holographic microscopy (DHM) is a marker-free quantitative phase microscopy technique for...

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PMID: 22262315
DOI: 10.1039/c2ib00129b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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