Article
The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: a case-control study and a meta-analysis.
Molecular biology reports - 1 Dec 2013
Coppedè Fabio, Bosco Paolo, Lorenzoni Valentina, Migheli Francesca, Barone Concetta, Antonucci Ivana, Stuppia Liborio, Romano Corrado, Migliore Lucia
Abstract excerpt
Methionine synthase (MTR) is required for the conversion of homocysteine (hcy) to methionine in the one-carbon metabolic pathway. Previous studies investigating a common MTR 2756A>G polymorphism as a maternal risk factor for the birth of a child with Down syndrome (DS) are conflicting and limited by small case-control cohorts, and its contribution to circulating hcy levels is still debated. We performed a large...
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