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Article

The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis.

Molecular biology reports - 1 Sept 2014

Coppedè Fabio, Bosco Paolo, Lorenzoni Valentina, Denaro Maria, Anello Guido, Antonucci Ivana, Barone Concetta, Stuppia Liborio, Romano Corrado, Migliore Lucia

Abstract excerpt

We performed a large case-control study and a meta-analysis of the literature to address the role of the methionine synthase reductase (MTRR) c.66A>G polymorphism as a maternal risk factor for the birth of a child with Down Syndrome (DS) among Caucasian women. A total of 253 mothers of a DS child (MDS) and 298 control mothers of Italian origin were included in the case-control study. The meta-analysis of previous...

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PMID: 24965145
DOI: 10.1007/s11033-014-3462-5

Genes

MTRR
MTR

Variants

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