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Article

MTRR 66A>G polymorphism as maternal risk factor for Down syndrome: a meta-analysis.

Genetic testing and molecular biomarkers - 1 Jan 2013

Amorim Márcia R, Lima Marcelo A Costa

Abstract excerpt

Down syndrome (DS) is the most common cause of mental retardation. Recent reports have investigated possible genetic factors that may increase maternal risk for DS. Methionine synthase reductase (5-methyltetrahydrofolate-homocysteine methyltransferase reductase MTRR) plays an important role in folic acid pathway and a common polymorphism (c.66A>G) has been associated with DS but results were controversial. This...

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Source

Identifiers

PMID: 23094987
DOI: 10.1089/gtmb.2012.0200

Genes

MTRR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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