Article
FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance.
Oncogene - 7 Aug 2014
Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes A R, Yagüe E, Monteiro L J, Kongsema M, Zona S, Man E P S, Tsang J W-H, Coombes R C, Wu K-J, Khoo U-S, Medema R H, Freire R, Lam E W-F
Abstract excerpt
FOXM1 is implicated in genotoxic drug resistance but its mechanism of action remains elusive. We show here that FOXM1-depletion can sensitize breast cancer cells and mouse embryonic fibroblasts (MEFs) into entering epirubicin-induced senescence, with the loss of long-term cell proliferation ability, the accumulation of γH2AX foci, and the induction of senescence-associated β-galactosidase activity and cell...
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