Article
ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance.
Molecular cancer therapeutics - 1 Jun 2011
Millour Julie, de Olano Natalia, Horimoto Yoshiya, Monteiro Lara J, Langer Julia K, Aligue Rosa, Hajji Nabil, Lam Eric W F
Abstract excerpt
In this report, we investigated the role and regulation of forkhead box M1 (FOXM1) in breast cancer and epirubicin resistance. We generated epirubicin-resistant MCF-7 breast carcinoma (MCF-7-EPI(R)) cells and found FOXM1 protein levels to be higher in MCF-7-EPI(R) than in MCF-7 cells and that FOXM1 expression is downregulated by epirubicin in MCF-7 but not in MCF-7-EPI(R) cells. We also established that there is...
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