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Article

Evaluating empirical bounds on complex disease genetic architecture.

Nature genetics - 1 Dec 2013

Agarwala Vineeta, Flannick Jason, Sunyaev Shamil, Altshuler David

Abstract excerpt

The genetic architecture of human diseases governs the success of genetic mapping and the future of personalized medicine. Although numerous studies have queried the genetic basis of common disease, contradictory hypotheses have been advocated about features of genetic architecture (for example, the contribution of rare versus common variants). We developed an integrated simulation framework, calibrated to...

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Identifiers

PMID: 24141362
DOI: 10.1038/ng.2804
PMCID: PMC4158716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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