Article
Genetic architecture of type 2 diabetes.
Biochemical and biophysical research communications - 19 Sept 2014
Hara Kazuo, Shojima Nobuhiro, Hosoe Jun, Kadowaki Takashi
Abstract excerpt
Genome-wide association studies (GWAS) have identified over 70 loci associated with type 2 diabetes (T2D). Most genetic variants associated with T2D are common variants with modest effects on T2D and are shared with major ancestry groups. To what extent the genetic component of T2D can be explained by common variants relies upon the shape of the genetic architecture of T2D. Fine mapping utilizing populations with...
Topics
- Chromosome Mapping
- Diabetes Mellitus, Type 2
- Ethnicity
- Gene Frequency
- Genetic Loci
- Genetic Variation
- Genome-Wide Association Study
- HapMap Project
- Humans
- Linkage Disequilibrium
- Molecular Sequence Annotation