Article
Heterozygous TREM2 mutations in frontotemporal dementia.
Neurobiology of aging - 1 Apr 2014
Borroni Barbara, Ferrari Francesca, Galimberti Daniela, Nacmias Benedetta, Barone Cinzia, Bagnoli Silvia, Fenoglio Chiara, Piaceri Irene, Archetti Silvana, Bonvicini Cristian, Gennarelli Massimo, Turla Marinella, Scarpini Elio, Sorbi Sandro, Padovani Alessandro
Abstract excerpt
A causative association was recently demonstrated between homozygous TREM2 mutations and frontotemporal dementia (FTD)-like syndrome and between heterozygous TREM2 exon2 genetic variations and late-onset Alzheimer's disease (AD). The objective of this study was to evaluate whether heterozygous TREM2 genetic variations might be associated to the risk of FTD. TREM2 exon 2 was sequenced in a group of 1030...
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