Article
Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes.
Neurobiology of aging - 1 Nov 2014
Thelen Mathias, Razquin Cristina, Hernández Isabel, Gorostidi Ana, Sánchez-Valle Raquel, Ortega-Cubero Sara, Wolfsgruber Steffen, Drichel Dmitriy, Fliessbach Klaus, Duenkel Tanja, Damian Marinella, Heilmann Stefanie, Slotosch Anja, Lennarz Martina, Seijo-Martínez Manuel, Rene Ramón, Kornhuber Johannes, Peters Oliver, Luckhaus Christian, Jahn Holger, Hüll Michael, Rüther Eckart, Wiltfang Jens, Lorenzo Elena, Gascon Jordi, Lleó Alberto, Lladó Albert, Campdelacreu Jaume, Moreno Fermin, Ahmadzadehfar Hojjat, Fortea Juan, Indakoetxea Begoña, Heneka Michael T, Wetter Axel, Pastor Maria A, Riverol Mario, Becker Tim, Frölich Lutz, Tárraga Lluís, Boada Mercè, Wagner Michael, Jessen Frank, Maier Wolfgang, Clarimón Jordi, López de Munain Adolfo, Ruiz Agustín, Pastor Pau, Ramirez Alfredo
Abstract excerpt
Frontotemporal dementia (FTD) is a clinically and genetically heterogeneous disorder. Rare TREM2 variants have been recently identified in families affected by FTD-like phenotype. However, genetic studies of the role of rare TREM2 variants in FTD have generated conflicting results possibly because of difficulties on diagnostic accuracy. The aim of the present study was to investigate associations between rare...
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