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Article

Deficiency in Aryl Hydrocarbon Receptor (AHR) Expression throughout Aging Alters Gene Expression Profiles in Murine Long-Term Hematopoietic Stem Cells.

PloS one - 1 Jan 2015

Bennett John A, Singh Kameshwar P, Unnisa Zeenath, Welle Stephen L, Gasiewicz Thomas A

Abstract excerpt

Dysregulation of hematopoietic stem cell (HSC) signaling can contribute to the development of diseases of the blood system. Lack of aryl hydrocarbon receptor (AhR) has been associated with alterations in gene expression related to HSC function and the subsequent development of a myeloproliferative disorder in aging female mice. We sorted the most primitive population of HSCs with the highest stem cell potential...

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Source

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Identifiers

PMID: 26208102
DOI: 10.1371/journal.pone.0133791
PMCID: PMC4514744

Genes

AHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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