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Article

Overexpression of DRAM enhances p53-dependent apoptosis.

Cancer medicine - 1 Feb 2013

Takahashi Masahiro, Kakudo Yuichi, Takahashi Shin, Sakamoto Yasuhiro, Kato Shunsuke, Ishioka Chikashi

Abstract excerpt

Tumor suppressor p53-dependent apoptosis is thought to be one of the most important tumor-suppressive mechanisms in human tumorigenesis. Till date, "super p53" mutants exhibiting more potent ability to induce apoptosis than wild-type p53 have been reported. These super p53s may provide a clue for development of novel therapeutic targets. However, the major mechanism underlying the super p53-dependent apoptosis...

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Identifiers

PMID: 24133622
DOI: 10.1002/cam4.39
PMCID: PMC3797565

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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