HLA-B*57 and IFNL4-related polymorphisms are associated with protection against HIV-1 disease progression in controllers.

doi:10.1093/cid/ciw833

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Article

HLA-B*57 and IFNL4-related polymorphisms are associated with protection against HIV-1 disease progression in controllers.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Mar 2017

Dominguez-Molina B, Tarancon-Diez L, Hua S, Abad-Molina C, Rodriguez-Gallego E, Machmach K, Vidal F, Tural C, Moreno S, Goñi J M, Ramírez de Arellano E, Del Val M, Gonzalez-Escribano M F, Del Romero J, Rodriguez C, Capa L, Viciana P, Alcamí J, Yu X G, Walker B D, Leal Manuel, Lichterfeld M, Ruiz-Mateos E

Abstract excerpt

Background: HIV-1-controllers maintain HIV-1 viremia at low levels (normally <2000 HIV-RNA copies/mL) without antiretroviral treatment. However, some HIV-1-controllers have evidence of immunologic progression with marked CD4+T-cell decline. We investigated host genetic factors associated with protection against CD4+T-cell loss in HIV-1-controllers. Methods: We analysed the association of interferon lambda 4...

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PMID: 27986689
DOI: 10.1093/cid/ciw833
PMCID: PMC5849048

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Source receipt: pubmed, retrieved 6 Sept 2026.

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