Article
Integrative Mouse and Human Studies Implicate ANGPT1 and ZBTB7C as Susceptibility Genes to Ischemic Injury.
Stroke - 1 Dec 2015
Du Rose, Zhou Jing, Lorenzano Svetlana, Liu Wenming, Charoenvimolphan Nareerat, Qian Baogang, Xu Jun, Wang Jian, Zhang Xinmu, Wang Xin, Berndt Annerose, Devan William J, Valant Valerie J, Wang Jinyi, Furie Karen L, Rosand Jonathan, Rost Natalia, Friedlander Robert M, Paigen Beverly, Weiss Scott T
Abstract excerpt
BACKGROUND AND PURPOSE: The extent of ischemic injury in response to cerebral ischemia is known to be affected by native vasculature. However, the nonvascular and dynamic vascular responses and their genetic basis are not well understood. METHODS: We performed a genome-wide association study in 235 mice from 33 inbred strains using the middle cerebral artery occlusion model. Population structure and genetic...
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