NRAS p.Q61R/K allele load is correlated to different phenotypes of congenital melanocytic naevi.

doi:10.1111/ced.15369

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Article

NRAS p.Q61R/K allele load is correlated to different phenotypes of congenital melanocytic naevi.

Clinical and experimental dermatology - 1 Dec 2022

Zhao Xiong, Dai Yefeng, Zhang Lulu, Liu Yuxin, Chen Hongyu, Yue Xiaojie, Yu Lan

Abstract excerpt

BACKGROUND: Congenital melanocytic naevi (CMN) are known to be associated with mosaic NRAS or BRAF variants. However, the exact correlations of the allele load of mosaic variants in CMN with phenotypic characteristics have not been determined. AIM: To determine the correlation of variants allele load and different phenotypes of CMN. METHODS: A panel of genes in the Ras/Raf/MAPK signalling pathway was selected for...

Topics

Humans
Proto-Oncogene Proteins B-raf
Alleles
Hypertrichosis
Skin Neoplasms
Phenotype
Nevus, Pigmented
Mutation
Membrane Proteins
GTP Phosphohydrolases

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PMID: 35962610
DOI: 10.1111/ced.15369

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