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Article

Human Rhinovirus–Induced Epithelial Production of CXCL10 Is Dependent upon IFN Regulatory Factor-1

30 Oct 2009

Abstract excerpt

Human rhinovirus (HRV) infections are associated with exacerbations of lower-airway diseases. HRV-induced production of proinflammatory chemokines, such as CXCL10, from infected airway epithelial cells may play a role in the pathogenesis of exacerbations. We have previously shown that the MAP/ERK kinase (MEK) pathway selectively down-regulates HRV-16-induced epithelial production of CXCL10 by modulating nuclear...

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PMID: 19880820
DOI: 10.1165/rcmb.2009-0203oc

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