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Article

In vitro and in silico analysis of the Aspergillus nidulans DNA-CreA repressor interactions.

Journal of biomolecular structure & dynamics - 1 Dec 2014

Esperón Patricia, Scazzocchio Claudio, Paulino Margot

Abstract excerpt

The CreA protein mediates carbon catabolite repression in the fungus Aspergillus nidulans. Its DNA-binding domain belongs to the Cys2-His2 class, binding specifically to a 5' SYGGRG 3' nucleotide sequence. EMSA experiments showed that the CreA(G27D) mutation resulted in a 30-fold increase of the Kdiss, and footprinting revealed a altered pattern of protein/DNA contacts. We modeled the CreA and the CreA(G27D)...

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Identifiers

PMID: 24125468
DOI: 10.1080/07391102.2013.843474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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