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Article

Optimization of minimum set of protein-DNA interactions: a quasi exact solution with minimum over-fitting.

Bioinformatics (Oxford, England) - 1 Feb 2010

Temiz N A, Trapp A, Prokopyev O A, Camacho C J

Abstract excerpt

MOTIVATION: A major limitation in modeling protein interactions is the difficulty of assessing the over-fitting of the training set. Recently, an experimentally based approach that integrates crystallographic information of C2H2 zinc finger-DNA complexes with binding data from 11 mutants, 7 from...

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PMID: 19965883
DOI: 10.1093/bioinformatics/btp664
PMCID: PMC2815656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19965883-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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