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Article

Mutations in the basic loop of the Zn binuclear cluster of the UaY transcriptional activator suppress mutations in the dimerisation domain.

Fungal genetics and biology : FG & B - 1 Sept 2012

Cecchetto Gianna, Richero Mariana, Oestreicher Nathalie, Muro-Pastor María Isabel, Pantano Sergio, Scazzocchio Claudio

Abstract excerpt

UaY is the specific ZnII(2)Cys(6) transcriptional activator of the purine utilisation pathway in Aspergillus nidulans. Previous work has determined the consensus binding sequence by EMSA and foot-printing. We determine here that it binds as a dimer to its cognate CGG-N(6)-CCG sites. We identify the uaY109 mutation, which has been shown to affect differentially the expression of a number of UaY-regulated genes, as...

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PMID: 22760060
DOI: 10.1016/j.fgb.2012.06.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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