Article
Towards computational specificity screening of DNA-binding proteins.
Nucleic acids research - 1 Oct 2011
Seeliger Daniel, Buelens Floris P, Goette Maik, de Groot Bert L, Grubmüller Helmut
Abstract excerpt
DNA-binding proteins are key players in the regulation of gene expression and, hence, are essential for cell function. Chimeric proteins composed of DNA-binding domains and DNA modifying domains allow for precise genome manipulation. A key prerequisite is the specific recognition of a particular nucleotide sequence. Here, we quantitatively assess the binding affinity of DNA-binding proteins by molecular...
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