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Article

MicroRNA-124 controls human vascular smooth muscle cell phenotypic switch via Sp1.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2017

Tang Yangfeng, Yu Shangyi, Liu Yang, Zhang Jiajun, Han Lin, Xu Zhiyun

Abstract excerpt

Phenotypic switch of vascular smooth muscle cells (VSMCs) plays an important role in the pathogenesis of atherosclerosis and aortic dissection. However, the mechanisms of phenotypic modulation are still unclear. MicroRNAs have emerged as important regulators of VSMC function. We recently found that microRNA-124 (miR-124) was downregulated in proliferative vascular diseases that were characterized by a VSMC...

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Identifiers

PMID: 28667053
DOI: 10.1152/ajpheart.00660.2016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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