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Article

CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression

14 Oct 2013

Abstract excerpt

Epithelial-mesenchymal transition is a change of cellular plasticity critical for embryonic development and tumor metastasis. CDK5 is a proline-directed serine/threonine kinase playing important roles in cancer progression. Here we show that CDK5 is commonly overexpressed and significantly correlated with several poor prognostic parameters of breast cancer. We found that CDK5 participated in TGF-β1-induced EMT....

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PMID: 24121667
DOI: 10.1038/srep02932

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