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Article

RB and p53 cooperate to prevent liver tumorigenesis in response to tissue damage.

Gastroenterology - 1 Oct 2011

McClendon A Kathleen, Dean Jeffry L, Ertel Adam, Fu Zhiyan, Rivadeneira Dayana B, Reed Christopher A, Bourgo Ryan J, Witkiewicz Agnieszka, Addya Sankar, Mayhew Christopher N, Grimes H Leighton, Fortina Paolo, Knudsen Erik S

Abstract excerpt

BACKGROUND & AIMS: The tumor suppressors retinoblastoma (RB) and p53 are important regulators of the cell cycle. Although human cancer cells inactivate RB and p53 by many mechanisms, the cooperative roles of these proteins in tumorigenesis are complex and tissue specific. We analyzed the cooperation of RB and p53 in liver development and pathogenesis of hepatocellular carcinoma. METHODS: Spontaneous and...

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Identifiers

PMID: 21704587
DOI: 10.1053/j.gastro.2011.06.046
PMCID: PMC4562673

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