Article
MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli.
Molecular cell - 1 Oct 2003
Zhang Yonglong, Zhang Junjie, Hoeflich Klaus P, Ikura Mitsuhiko, Qing Guoliang, Inouye Masayori
Abstract excerpt
Escherichia coli contains operons called "addiction modules," encoding toxin and antitoxin, which are responsible for growth arrest and cell death. Here, we demonstrate that MazF toxin encoded by "mazEF addiction module" is a sequence-specific (ACA) endoribonuclease functional only for single-stranded RNA. MazF works as a ribonuclease independent of ribosomes, and is, therefore, functionally distinct from RelE,...
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