Article
Poor prognosis of rare sarcomeric gene variants in patients with dilated cardiomyopathy.
Clinical and translational science - 1 Dec 2013
Merlo Marco, Sinagra Gianfranco, Carniel Elisa, Slavov Dobromir, Zhu Xiao, Barbati Giulia, Spezzacatene Anita, Ramani Federica, Salcedo Ernesto, Di Lenarda Andrea, Mestroni Luisa, Taylor Matthew R G
Abstract excerpt
BACKGROUND: In dilated cardiomyopathy (DCM), the clinical and prognostic implications of rare variants in sarcomeric genes remain poorly understood. To address this question, we analyzed the outcome of rare sarcomeric gene variants in patients enrolled in our Familial Cardiomyopathy Registry. METHODS: DCM families harboring rare sarcomeric variants in MYH6, MYH7, MYBPC3, TNNT2, and TTN were identified....
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