Article
A Wide and Specific Spectrum of Genetic Variants and Genotype-Phenotype Correlations Revealed by Next-Generation Sequencing in Patients with Left Ventricular Noncompaction.
Journal of the American Heart Association - 30 Aug 2017
Wang Ce, Hata Yukiko, Hirono Keiichi, Takasaki Asami, Ozawa Sayaka Watanabe, Nakaoka Hideyuki, Saito Kazuyoshi, Miyao Nariaki, Okabe Mako, Ibuki Keijiro, Nishida Naoki, Origasa Hideki, Yu Xianyi, Bowles Neil E, Ichida Fukiko
Abstract excerpt
BACKGROUND: Left ventricular noncompaction (LVNC) has since been classified as a primary genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present study was to identify the genetic spectrum using next-generation sequencing and to evaluate genotype-phenotype correlations in LVNC patients. METHODS AND RESULTS: Using next-generation sequencing, we targeted and sequenced 73 genes...
Topics
- Child, Preschool
- DNA Mutational Analysis
- Defibrillators, Implantable
- Disease-Free Survival
- Electric Countershock
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Markers