Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry.

doi:10.1016/j.jacc.2026.03.054

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Article

Sex and Age Specific Genetic Risk Across the Dilated and Arrhythmogenic Cardiomyopathy Spectrum: Insights From the SHaRe Registry.

Journal of the American College of Cardiology - 30 Jun 2026

Stroeks Sophie L V M, Bart Nicole K, Rossano Joseph, Claggett Brian, Beelen Nina J, Buchan Rachel J, Day Sharlene, Fornaro Alessandra, Halliday Brian P, Wheeler Matthew T, Hammersley Daniel J, Helms Adam, Heymans Astrid B M, Ho Carolyn Y, Khan Sadiya S, Lin Kim, Lota Amrit, Merlo Marco, Mestroni Luisa, Olivotto Iacopo, Owens Anjali, Seidman Christine E, Shore Supriya, Sinnette Corine, Sinagra Gianfranco, Stevenson Lynne W, Stewart Garrick C, Theotakis Pantazis, Venner Max F G H M, Ware James S, Taylor Matthew R G, Verdonschot Job A J, Wilsbacher Lisa, Prasad Sanjay, Heymans Stephane R, Parikh Victoria N, Tayal Upasana, Lakdawala Neal K

Abstract excerpt

BACKGROUND: Dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) are progressive cardiac muscle disorders with phenotypic and genetic overlap. Although a male predominance is noted in DCM/ACM, it remains unclear whether this extends to specific genetic subtypes or reflects variation in disease stage and whether sex influences age-dependent disease onset across pediatric and adult groups....

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