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Article

Genetic determinants of immunogenicity to factor IX during the treatment of haemophilia B.

Haemophilia : the official journal of the World Federation of Hemophilia - 1 Mar 2015

Saini S, Hamasaki-Katagiri N, Pandey G S, Yanover C, Guelcher C, Simhadri V L, Dandekar S, Guerrera M F, Kimchi-Sarfaty C, Sauna Z E

Abstract excerpt

Inhibitors are an impediment to the effective management of haemophilia B (HB), but there is limited understanding of the underlying genetic risk factors. In this study we aim to understand the role of F9 gene mutations on inhibitor development in patients with HB. Mutations in the F9 gene were identified and HLA typing performed for five boys with severe HB. Data from the CDC Haemophilia B Mutation Project...

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PMID: 25470321
DOI: 10.1111/hae.12553

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