Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A large-scale computational study of inhibitor risk in non-severe haemophilia A.

British journal of haematology - 1 Feb 2015

Shepherd Adrian J, Skelton Stuart, Sansom Clare E, Gomez Keith, Moss David S, Hart Daniel P

Abstract excerpt

Over 500 missense F8 mutations have been reported to cause non-severe haemophilia A. Some F8 genotypes appear to confer a higher risk of inhibitor formation than others and individuals with the same F8 genotype may have differing risks of inhibitor formation. We present an in silico strategy demonstrating the heterogeneity of factor VIII (FVIII)-derived antigen presentation whilst identifying patterns of human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigen Presentation
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Coagulation Factor Inhibitors

Share to Computer Simulation

Share to Factor VIII

Share to Hemophilia A

Share to HLA-DR Antigens

Share to Predictive Value of Tests

Source

Identifiers

PMID: 25244644
DOI: 10.1111/bjh.13131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A large-scale computational study of inhibitor risk in non-severe haemophilia A.PMID 25244644Read ↗

FVIII Immunogenicity-Bioinformatic Approaches to Evaluate Inhibitor Risk in Non-severe Hemophilia A.Semantic proximity Read ↗

<i>In silico</i> calculated affinity of FVIII‐derived peptides for <scp>HLA</scp> class II alleles predicts inhibitor development in haemophilia A patients with missense mutations in the F8 geneSemantic proximity Read ↗

HLA Variants and Inhibitor Development in Hemophilia A: A Retrospective Case-Controlled Study Using the ATHNdatasetSemantic proximity Read ↗

Polymorphisms in the F8 gene and MHC-II variants as risk factors for the development of inhibitory anti-factor VIII antibodies during the treatment of hemophilia a: a computational assessment.Semantic proximity Read ↗

In silico analyses of missense mutations in coagulation factor VIII: identification of severity determinants of haemophilia A.Semantic proximity Read ↗

Treatment burden, haemostatic strategies and real world inhibitor screening practice in non-severe haemophilia A.Semantic proximity Read ↗

Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research RepositorySemantic proximity Read ↗

Mutational landscape, inhibitor development, and health-care burden in non-severe haemophilia A: A single-centre Australian experience.Semantic proximity Read ↗

Genetic risk factors for inhibitors in haemophilia A.Semantic proximity Read ↗

Prediction of factor VIII inhibitor development in the SIPPET cohort by mutational analysis and factor VIII antigen measurement.Semantic proximity Read ↗

Performance of a clinical risk prediction model for inhibitor formation in severe haemophilia A.Semantic proximity Read ↗

Novel F8 and F9 gene variants from the PedNet hemophilia registry classified according to ACMG/AMP guidelines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.