Article
Two functional variants of IRF5 influence the development of macular edema in patients with non-anterior uveitis.
PloS one - 1 Jan 2013
Márquez Ana, Cénit María Carmen, Cordero-Coma Miguel, Ortego-Centeno Norberto, Adán Alfredo, Fonollosa Alejandro, Díaz Valle David, Pato Esperanza, Blanco Ricardo, Cañal Joaquín, Díaz-Llopis Manuel, de Ramón Enrique, Del Rio María José, García Serrano José Luis, Artaraz Joseba, Martín-Villa José Manuel, Llorenç Víctor, Gorroño-Echebarría Marina Begoña, Martín Javier
Abstract excerpt
OBJECTIVE: Interferon (IFN) signaling plays a crucial role in autoimmunity. Genetic variation in interferon regulatory factor 5 (IRF5), a major regulator of the type I interferon induction, has been associated with risk of developing several autoimmune diseases. In the current study we aimed to evaluate whether three sets of correlated IRF5 genetic variants, independently associated with SLE and with different...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.