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Article

Mechanisms of Acquired Resistance to Targeted Cancer Therapies

15 Aug 2012

Abstract excerpt

Drugs that target genomically defined vulnerabilities in human tumors have now been clinically validated as effective cancer therapies. However, the relatively rapid acquisition of resistance to such treatments that is observed in virtually all cases significantly limits their utility and remains a substantial challenge to the clinical management of advanced cancers. As molecular mechanisms of resistance have...

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PMID: 22894672
DOI: 10.2217/fon.12.86

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