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Article

Functional principal component analysis reveals discriminating categories of retinal pigment epithelial morphology in mice.

Investigative ophthalmology & visual science - 5 Nov 2013

Jiang Yi, Qi Xin, Chrenek Micah A, Gardner Christopher, Boatright Jeffrey H, Grossniklaus Hans E, Nickerson John M

Abstract excerpt

PURPOSE: To determine whether multivariate, functional principal component analysis of the size and shape of retinal pigment epithelial (RPE) cell morphology allows discrimination of mouse RPE genotypes and age. METHODS: Flatmounts of RPE sheets obtained from C57BL/6J (n = 50) and rd10 (n = 61) mice at postnatal days 30 to 720 were stained for zonula occludens-1 (ZO-1) and imaged with confocal microscopy. A total...

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Source

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Identifiers

PMID: 24114543
DOI: 10.1167/iovs.13-12450
PMCID: PMC4086880

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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